A Scientific Breakthrough, Engineered To Help You Age Better



A scientific breakthrough, engineered to help you age better

As our NAD+ levels decline with age, supplementation with TRU NIAGEN® is a safe, efficient, science-based strategy to replenish NAD+, maintain energy, and optimize our health span.*

NAD+ is vital to cellular health

  • Repairs DNA damage
  • Defends against free radicals
  • Controls cellular metabolism
  • Regulates our "longevity" genes



From the scientist that discovered the secret to replenishing our NAD+ supply.


Charles Brenner, PhD is the world's foremost authority on NAD+. He is Head of Biochemistry and Professor of Internal Medicine at the University of Iowa, and co-founder of ProHealthspan, LLC.
  • For over a century scientists have been conducting experiments to understand what internal factors drive aging. Their research led them to a critical coenzyme called NAD+ which controls cellular metabolism, and sirtuin "longevity" genes, which play a critical role in aging and our long-term health. More recently, scientists discovered that our NAD+ levels naturally decline as we age, leading to a decline in overall cellular health. This discovery led to one question:

    Can we sustain NAD+ levels over time?

    In order to find the answer, scientists began researching the few compounds that your body can convert into NAD+. They are called NAD+ precursors, and for years they believed that there were only two vitamin precursors to NAD+ in existence, and both had issues of inefficiency and/or adverse side effects.

    But in 2004, Dr. Brenner and his team at Dartmouth College made an incredible discovery. There is indeed a third vitamin precursor to NAD+ and it has proven to be both highly efficient and safe. It is called Nicotinamide Riboside (NR) and it has ignited the scientific community around aging, spawning hundreds of recent studies. Now it is finally available to you in the form of a daily supplement called TRU NIAGEN®.

Active Ingredient

Nicotinamide Riboside (NR): Discovered by Dr. Brenner to be the most efficient precursor to NAD+. It is used by all cells to create NAD+.



GRAS (Generally Recognized as Safe) certified

New Dietary Ingredient status from the FDA

Clinically proven to raise NAD levels

Specifically targeted by stressed and damaged cells

Activates the sirtuin "longevity" genes

Certified by the NSF, leading independent public health and safety organization


  • Recommended Use - Take two capsules every morning with or without food. Each bottle contains a 30-day supply. Read More
  • Purity - TRU NIAGEN® is manufactured in California under cGMP (current Good Manufacturing Practice) regulations, enforced by the FDA. It is certified by the NSF, a leading independent public health and safety organization, and each lot undergoes rigorous third party testing to confirm purity. Read More
  • Feedback - Subtle changes in overall feeling of well-being, energy consistency, cognitive function, quality of sleep, and quicker recovery after exercise are often reported within 4-16 weeks of starting. Note that cellular health may not always manifest results at the surface. Read More
  • Dietary - TRU NIAGEN® is vegetarian, vegan, gluten-free, nut-free, and contains no artificial colors or flavors. Read More


Prominent researchers from America’s finest institutions including Harvard, MIT, and Dartmouth have already published studies on these vital topics:


Administering NR for NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Full Study


By elevating NAD+, supplementation with NR promotes resistance to diet-induced obesity. Full Study


NR greatly reduced blood glucose, weight gain, liver damage and the development of hepatic steatosis in prediabetic and type 2 diabetic mice while protecting against sensory neuropathy. Full Study


In a mouse model of Alzheimer’s, mice treated with NR performed better at cognitive tests. Full Study


ProHealthspan is the official partner of ChromaDex, Inc.

Chromadex is an innovative natural products company that discovers, acquires, develops and commercializes proprietary-based ingredient technologies. ChromaDex has licensed the key enabling NR technologies from Dartmouth College and other institutions, and is the worldwide patent-holder and sole manufacturer of NIAGEN®. NIAGEN® is a registered trademark of ChromaDex, Inc.



NIAGEN® is the first and only commercially available, patented form of nicotinamide riboside. Each capsule of TRU NIAGEN® contains 125 milligrams of NIAGEN®.

The NIAGEN® in TRU NIAGEN® is proven to boost levels of NAD+, a coenzyme found in all living cells*. NAD+ plays a key role in cell function within the “powerhouses of the cell”, the mitochondria. Mitochondria produce energy for our cells, and play an important role in the aging process. A deficiency of NAD+ is one of the main causes of cellular aging and breakdown. Find out more. here.

No one can predict your individual results, but the evidence behind NIAGEN® is strong and exciting. Research has shown that NIAGEN® can improve cellular health, energy and muscle endurance, help protect the heart and nerves, protect against weight gain on a high-fat diet, and much more. There are also many anecdotal (individual) reports of better sleep, improved skin appearance, and stronger hair and nails.* For more on the clinical research, click. here.

NIAGEN® is the trademarked name for Nicotinamide Riboside (NR). NR is a natural product that is present in milk. What’s more, a panel of scientific experts unanimously found that NIAGEN®, a nature-identical nicotinamide riboside, is Generally Recognized as Safe (GRAS) in accordance with regulations from the Food and Drug Administration (FDA). GRAS status means that nicotinamide riboside is safe to use in foods and beverages. NIAGEN® has also received New Dietary Ingredient status from the FDA

TRU NIAGEN® comes to you from Healthspan Research, LLC, a California-based supplements company that is the Official Partner of ChromaDex, Inc., another California firm. ChromaDex pioneered NIAGEN®, and holds the worldwide patents on this breakthrough product. Read more about Healthspan Research.

No—lifespan is simply the number of years you live, whatever the quality of your health. The number of years you enjoy healthy living is your healthspan.

Your TRU NIAGEN® purchase is covered by a 30-day, money-back guarantee.

Absolutely. We encourage buying more than one bottle, as it can take several weeks to begin feeling the effects of healthier cells. To see how buying in bulk helps you save, click here .

Everyone is different and responds to TRU NIAGEN® in their own unique ways. Some people feel greater energy, deeper sleep and more mental alertness in just a few days. For others, noticing a difference in overall vitality and wellness can take longer. Even if you don’t see changes right away, know that TRU NIAGEN® is working at the cellular level—at the very foundation of life—to help you enjoy better health and well being.

There have been more than 100 scientific studies on NIAGEN® (NR) and NAD+ from some of the most influential and prestigious scientists and institutions in the world. NIAGEN® (NR) has been clinically shown to increase NAD+ levels in humans, and has been shown to have profound effects in model systems in the categories of anti-aging, energy, heart health, brain function, sleep and weight loss. Researchers at Harvard, MIT, Dartmouth, Cornell, Iowa and others have been publishing, and continue to publish NIAGEN® (NR) related studies almost monthly. For a closer look, click here.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.