What is NIAGEN®?

NIAGEN® is the first and only commercially available form of nicotinamide riboside (NR), a naturally-occurring compound found in trace amounts in milk.  It is the product of decades of groundbreaking scientific research conducted by ProHealthspan's Co-Founder and Chief Scientist, Charles Brenner, PhD.

Why is NIAGEN® important? 

In 2004, our co-founder and Chief Scientist, Dr. Charles Brenner made a breakthrough discovery that ignited the science and research behind metabolism and aging.  Before Dr. Brenner's discovery there were only three known precursors for NAD(a widely studied, and very important metabolite), namely tryptophan, niacin and nicotinamide.  Tryptophan, is not efficiently converted  to NAD+, while niacin causes an undesirable side effect referred to as the "niacin flush" in which the skin becomes red and warm, often accompanied by a burning sensation and itching.  The third, nicotinamide, inhibits sirtuins.  

Thus, while everyone wanted to increase the activity of sirtuins and elevate NAD+ in order to boost metabolism, there was no practical way to do it.

Dr. Brenner’s discovery of NR as a vitamin precursor of NAD+ that doesn’t cause flushing and doesn’t inhibit sirtuins paved the way for its patented commercialization as NIAGEN® by ChromaDex.

    TRU NIAGEN®: Patented, tested, proven, and safe

    This first human clinical study on NIAGEN® has landmark importance. Not only does it show that NIAGEN® can actually boost levels of NAD+ in a single dose - it reveals no safety issues, which is consistent with the safety results demonstrated in many other studies. View the full report.

    With TRU NIAGEN®, the official partner of ChromaDex, Inc., you can be sure that you are getting the patented and tested NIAGEN® straight from the company that pioneered it.  Every bottle of TRU NIAGEN® has to meet the highest standards of potency, purity and third-party certification.

    TRU NIAGEN® is manufactured under cGMP (current Good Manufacturing Practice) regulations, enforced by the Food and Drug Administration, in a facility certified by the NSF, a leading independent public health and safety organization.

    NIAGEN® has two important “pedigrees” in the field of nutritional supplements:

    • NIAGEN® has achieved status as a New Dietary Ingredient by the Food and Drug Administration.
    • NIAGEN® has achieved GRAS (Generally Recognized As Safe) status by an independent scientific panel.


     *These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.